These results show that the median nerve stimulation paradigm provides considerable sensitivity to age- and gender-related differences. In addition, females had larger peak amplitude responses than males in the contralateral secondary somatosensory timecourse (approximately 28 and 51 ms). We found early, large amplitude responses in the elderly in primary somatosensory (approximately 20 ms) and pre-central sulcus timecourses (approximately 22 ms) and lower amplitude responses in the elderly later in primary somatosensory (approximately 32 ms) and contralateral secondary somatosensory timecourses (approximately 90 ms). After measuring the MEG responses, we modeled the data using a spatio-temporal multi-dipole modeling approach to determine the source locations and their associated timecourses.
Thirty-four healthy subjects from two age groups: 20-29 and >64 years of age were examined. The current study uses magnetoencephalography (MEG) to characterize age-related changes and gender differences in the amplitudes and timing of cortical sources evoked by median nerve stimulation. Stephen, Julia M Ranken, Doug Best, Elaine Adair, John Knoefel, Janice Kovacevic, Sanja Padilla, Denise Hart, Blaine Aine, Cheryl J Copyright © 2011 Wiley Periodicals, Inc.Īging changes and gender differences in response to median nerve stimulation measured with MEG. The rate of change of median conduction velocity was significantly greater than for the ulnar nerve. The rate of change for the median conduction velocity was higher than previously reported. The rates of change in amplitudes did not differ, but the median nerve demonstrated a more rapid loss of conduction velocity. Corresponding values for the ulnar nerve were 0.89 μV and 0.29 m/s per year. Amplitudes of the median sensory nerve action potentials decreased by 0.58 μV per year, whereas conduction velocity decreased at a rate of 0.41 m/s per year. The rate of change in the nerve parameters was estimated while controlling for gender, age, change in hand temperature, baseline body mass index (BMI), and change in BMI.
Seven hundred four subjects had at least two observations. Median and ulnar sensory nerves were tested at the annual meetings of the American Dental Association. Nerve conduction velocity slows and amplitude declines with aging. Werner, Robert A Franzblau, Alfred D'Arcy, Hannah J S Evanoff, Bradley A Tong, Henry C
Differential aging of median and ulnar sensory nerve parameters.
0 kommentar(er)
